Tissue changes induced by cyanoacrylate-based glues used to fix a light polyvinylidene fluoride (PVDF) mesh in a rat model

For their quick action and binding strength, cyanoacrylate (CA)-based tissue adhesives can be used instead of sutures to fix meshes used for hernia repair. The current study's objective was to evaluate the tissue alterations induced by CA glues of a different formulation used to fix mesh for hernia repair in a rat models. l. In 40 rats, parietal defects were induced in the abdomen wall, which were then repaired using polyvinylidene fluoride mesh fixed by two different types of CA glue. (Glubran® Tiss 2, GEM s.r.l., Viareggio, Italy and Histoacryl, BBraun Corp., Germany). Macroscopic and histological examinations were carried out to assess mesh fixation , the existence of complications, and tissue responses at one day, seven days, fifteen days, and thirty days after fixation.. Because there were no symptoms of inflammation, displacement, or detachment, the tissue adhesives were effective and had a good biocompatibility. The initial tissue response was minimal and transient in the areas where CA glues were used. Collagen fibrils production around prosthetic components began 7 days after implantation and collagen maturation was achieved 30 days after surgery, ensuring a successful mesh integration. The fixation of the mesh with the Glubran® Tiss 2 glue induced a minor inflammatory reaction and a minor foreign body reaction while inducing a good production of connective tissue necessary for fixing the prosthetic material. In conclusion, our research demonstrated that the two CA adhesives tested caused a successful integration of mesh into host abdominal wall with few complication and a good tolerance as testified by a diminished acute tissue reactivity.

氰基丙烯酸酯（cyanoacrylate，CA）基组织胶凭借其快速固化特性与优异粘结强度，可替代缝线用于疝修补术的补片固定。本研究旨在评估两种不同配方的CA胶应用于大鼠疝修补补片固定时所诱导的组织变化。本研究选取40只大鼠，于其腹壁制造壁层缺损，随后采用两种不同类型的CA胶（分别为意大利维亚雷焦GEM s.r.l.公司生产的Glubran® Tiss 2，以及德国贝朗公司的Histoacryl）固定聚偏氟乙烯（polyvinylidene fluoride，PVDF）补片以完成缺损修补。分别于补片固定后1天、7天、15天及30天进行大体观察与组织学检查，以评估补片固定效果、并发症发生情况及组织反应。实验未观察到炎症、移位或脱落相关症状，表明该组织胶效果优异且生物相容性良好。使用CA胶的区域初始组织反应轻微且呈一过性。植入术后7天，假体周围开始出现胶原纤维生成；术后30天胶原完全成熟，可确保补片与宿主组织成功整合。其中，采用Glubran® Tiss 2胶固定补片仅诱导轻微炎症反应与异物反应，同时可良好生成固定假体所需的结缔组织。综上，本研究证实本次测试的两种CA胶均可实现补片与宿主腹壁的成功整合，并发症发生率低且耐受性良好，急性组织反应减弱即可佐证这一结论。