LS CE-Chirp® vs. Click in the neuroaudiological diagnosis by ABR

Abstract Introduction: The chirp stimulus was developed seeking to counterbalance the delay of the sound wave on its journey through the cochlea, allowing the hair cells to depolarize at the same time. The result is a simultaneous stimulation providing better neural synchrony and, consequently, the recording of responses with greater amplitudes. Objective: To compare the absolute latency of waves I, III and V, the interpeak intervals I-III, III-V and I-V, amplitude values of wave V and its association with the amplitude of wave I, and the interaural difference V-V in the auditory brainstem response (ABR) using Click and LS CE-Chirp® stimuli to determine whether the responses evoked by LS CE-Chirp® could be applied to neuroaudiological diagnosis. Methods: Cross-sectional study with 30 normal-hearing individuals. The parameters used were: intensity of 85 dBnHL, alternating polarity; 17.1 stimuli/s and 100-3000 Hz filters. Results: The absolute latencies of waves I, III and V observed with LS CE-Chirp® and click did not show significant differences. Significantly higher amplitudes of wave V were observed with the LS CE-Chirp®. The interaural difference between the wave V latencies between stimuli showed no significant difference. Conclusion: The LS CE-Chirp® stimulus was shown to be as efficient as the click to capture ABR at high levels of stimulation, with the advantage of producing greater-amplitude V waves.引言：本研究开发啁啾刺激（chirp stimulus），旨在抵消声波经耳蜗传导时的延迟，使毛细胞能够同步去极化。该刺激可实现同步刺激，从而提升神经同步性，最终可记录到振幅更高的响应信号。 目的：比较短声（Click）与LS CE-Chirp®刺激下，听性脑干反应（auditory brainstem response, ABR）的Ⅰ、Ⅲ、Ⅴ波绝对潜伏期，Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ峰间期，Ⅴ波振幅值及其与Ⅰ波振幅的相关性，以及双侧Ⅴ波潜伏期的耳间差异，以明确LS CE-Chirp®诱发电位是否可应用于神经听力学诊断。 方法：本研究为横断面研究，纳入30名听力正常受试者。测试参数设置如下：刺激强度为85 dBnHL，采用交替极性，刺激率17.1次/秒，滤波带宽为100~3000 Hz。 结果：采用LS CE-Chirp®与短声刺激时，Ⅰ、Ⅲ、Ⅴ波的绝对潜伏期无显著统计学差异；LS CE-Chirp®诱发出的Ⅴ波振幅显著更高。两种刺激下的双侧Ⅴ波潜伏期耳间差异均无统计学意义。 结论：在高刺激强度下，LS CE-Chirp®刺激获取听性脑干反应的效果与短声相当，且具备诱发出振幅更高的Ⅴ波这一优势。