Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131

Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131 Descriptor: 1-(2-{3-[(1E)-N-(2-aminoethoxy)ethanimidoyl]phenyl}propan-2-yl)-3-(4-chloro-3-nitrophenyl)urea, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Kim, Y, Makowska-Grzyska, M, Gu, M, Kavitha, M, Hedstrom, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2014-11-25 Release date: 2014-12-31 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.053 Å) Cite: Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun, 71, 2015

小隐孢子虫（Cryptosporidium parvum）次黄嘌呤单核苷酸脱氢酶（inosine monophosphate dehydrogenase）催化结构域与抑制剂p131共晶结构
描述：1-(2-{3-[(1E)-N-(2-氨基乙氧基)亚氨代乙酰基]苯基}丙-2-基)-3-(4-氯-3-硝基苯基)脲、二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）、甘油（GLYCEROL）等。
作者：Kim, Y、Makowska-Grzyska, M、Gu, M、Kavitha, M、Hedstrom, L、Anderson, W.F、Joachimiak, A；传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）
提交日期：2014-11-25
发布日期：2014-12-31
最后修改日期：2023-12-06
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.053 Å）
引用文献：《隐孢子虫IMP脱氢酶结合具有体内抗寄生虫活性抑制剂的结构》，《Acta Crystallogr F Struct Biol Commun》，71卷，2015年