Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles

A mild, room-temperature Pd-catalyzed acetoxylation of pyrroles with phenyliodonium acetate is described. The acetoxylation was found to proceed via the initial formation of pyrrolyl(phenyl)iodonium acetates, which were converted to acetoxypyrroles in the presence of Pd(OAc)2. The acetoxylation could also be carried out as a one-pot sequential procedure without the isolation of the intermediate iodonium salts.

本文报道了一种温和的室温钯催化吡咯(Pyrroles)与乙酸碘苯鎓(Phenyliodonium acetate)的乙酰氧基化反应。研究发现，该乙酰氧基化反应首先生成吡咯基(苯基)碘鎓乙酸酯中间体，随后在Pd(OAc)₂存在下转化为乙酰氧基吡咯。该乙酰氧基化反应亦可采用一锅法连续操作，无需分离中间体碘鎓盐。