In vitro evaluation of antifungal combinations against neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosis (Supplemental_data_tables_S1-S20)

This research evaluated the in vitro activities of nine antifungal drugs and their combinations against neurotropic melanized fungi associated with cerebral phaeohyphomycosis. To our knowledge, this is the first study to assess the in vitro activities of 13 double and five triple antifungal combinations against three common causative agents of fungal brain abscess in humans. We developed and standardized a simple and cost-effective method of testing double and triple combinations of antifungal agents, using a modified version of checkerboard assay. This dataset shows the drug dilution scheme and final microplate configurations for antifungal combinations in two- and three-dimensional checkerboard assays.

本研究评估了9种抗真菌药物及其联合用药方案针对与脑暗色丝孢霉病（cerebral phaeohyphomycosis）相关的嗜神经产黑色素真菌的体外抗菌活性。据我们所知，本研究为首项针对3种常见人类真菌性脑脓肿致病原，评估13种双重抗真菌联合方案与5种三重抗真菌联合方案体外活性的研究。本研究采用改良版棋盘格法（checkerboard assay），开发并标准化了一种简便且经济高效的抗真菌药物双重、三重联合用药检测方法。本数据集涵盖了二维及三维棋盘格试验中，抗真菌联合用药的药物稀释方案与最终微孔板构型信息。