JAAD Supplemental Material -Sports bras improve chest keloids but outcomes are dependent on breast size: a retrospective analysis

Supplemental Figure 1. Study design and flow chart of the medical records selection in two groups.

Supplemental Figure 2. Effect of sports bra and breast size on keloid score after the combination treatment.
(a) The keloid scores in without sports bra group are significantly worse than scores in with sports bras group at 1-year follow-up. (b-c) The large breast size group (BSS＜7.7) shows more significant improvement of keloid score when patients wear sports bras than the small breast size group (BSS＞7.7). (d) Larger size of the breast is correlated to the worse keloid score in both two groups according to simple Linear Regression. However, the positive association in without sports bra group is stronger compared to with sports bra group.

Supplemental Figure 3. Impact of time of keloid onset and age of patient on the treatment outcome.
The result shows that the keloid score is not statistically correlated to the time of keloid onset or the age of patients in both groups.

Supplemental Figure 4. The clinical pictures of patients in both groups before and one year after operation.
The patients in with sports bra group exhibit milder erythema and telangiectasia and smaller vertical width of lesion one year after treatment compared to patients in without sports bra group.

Supplemental Figure 5. The typical pathological features of one of included patients.
(a) Low-power view shows the collagen is separated by small bundles of sparsely cellular fibroblastic tissue and chronic inflammatory cells. (b) High-power view highlights typical broad, hyalinized, and eosinophilic “bubble gum” collagen fibers. In addition, the lack of epidermal appendages is noted on both low and high power. (a, hematoxylin-eosin, original magnification×40; b, H&E, original magnification×200)

补充图1 两组病历筛选的研究设计与流程图。

补充图2 运动内衣（sports bra）与乳房尺寸对联合治疗后瘢痕疙瘩（keloid）评分的影响。(a) 术后1年随访时，未佩戴运动内衣组的瘢痕疙瘩评分显著差于佩戴运动内衣组。(b-c) 大乳房尺寸组（乳房尺寸评分BSS＜7.7）在佩戴运动内衣时，瘢痕疙瘩评分的改善程度显著优于小乳房尺寸组（BSS＞7.7）。(d) 简单线性回归（simple linear regression）分析显示，两组中乳房尺寸越大，瘢痕疙瘩评分越差。不过未佩戴运动内衣组的正相关强度高于佩戴运动内衣组。

补充图3 瘢痕疙瘩发病时间与患者年龄对治疗结局的影响。结果显示，两组中瘢痕疙瘩评分均与瘢痕疙瘩发病时间或患者年龄无统计学相关性。

补充图4 两组患者术前及术后1年的临床照片。与未佩戴运动内衣组患者相比，佩戴运动内衣组患者在治疗后1年的红斑（erythema）、毛细血管扩张（telangiectasia）程度更轻，病变垂直宽度更小。

补充图5 纳入患者之一的典型病理特征。(a) 低倍镜下可见胶原纤维被稀疏细胞性成纤维组织束与慢性炎症细胞分隔。(b) 高倍镜下可见典型的宽阔、玻璃样变且嗜酸性的“口香糖样”胶原纤维。此外，低倍与高倍镜下均可见表皮附属器缺失。(a，苏木精-伊红（hematoxylin-eosin，H&E）染色，原始放大倍数×40；b，H&E染色，原始放大倍数×200)