Observation of synergistic antibacterial properties of Prodigiosin from Serratia marcescens jx-1 with metal ions in clinical isolates of Staphylococcus aureus

Data showed we obtained clinical isolates of Staphylococcus aureus including Methicillin-resistant S. aureus (MRSA) and Methicillin-sensitive S. aureus (MSSA) strains and evaluated the antibacterial efficacy of prodigiosin alone or in combination with different metal ions on clinical isolates of MRSA and MSSA strains. The results showed the metal ions Cu(II), Al(III), and Zn(II) can inhibit the cell growth of MRSA and MSSA at concentrations between 0.1 mM and 1.5 mM. and we found that also Zn(II) and Al(III) in combination with PG resulted in a significant synergistic antibacterial effect against MRSA and MSSA.

本研究数据表明，我们获取了包括耐甲氧西林金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）在内的临床分离株，并评估了红霉素单独或与不同金属离子联合作用于MRSA和MSSA临床分离株的抗菌活性。研究结果显示，铜离子Cu(II)、铝离子Al(III)和锌离子Zn(II)在0.1 mM至1.5 mM的浓度范围内可以抑制MRSA和MSSA的细胞生长。此外，我们发现，Zn(II)和Al(III)与PG联合使用，对MRSA和MSSA具有显著的协同抗菌效应。