Reductive Homocondensation of Benzylidene- and Alkylidenepyruvate Esters by a P(NMe₂)₃‑Mediated Tandem Reaction

A reductive homocondensation of E-benzylidenepyruvate esters mediated by P(NMe2)3 is described. The transformation, initiated by the Kukhtin–Ramirez addition of the phosphorus reagent to the vinyl-substituted α-dicarbonyl substrate, proceeds via a resonance delocalized oxyphosphonium dienolate intermediate to provide access to diverse oxygenated heterocycles as a function of the substituent.本文报道了由三(二甲氨基)膦(P(NMe₂)₃)介导的E-亚苄基丙酮酸酯的还原均缩合反应。该转化以磷试剂对乙烯基取代α-二羰基底物的库赫廷-拉米雷斯(Kukhtin–Ramirez)加成为起始步骤，经由共振离域的氧鎓二烯醇盐中间体进行，最终可根据取代基的差异得到多种含氧杂环化合物。