Additional file 1: Table S1. of Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

MetaCore analysis of fold changes in expression of all genes in SINE compound-resistant versus parental cells post-treatment. FDR = Benjamini-Hochberg False Discovery Rate. Red = positive, blue = negative, color intensity corresponds to fold change magnitude. Table S2. MetaCore analysis of fold changes in expression of genes with p53 regulatory elements in SINE compound-resistant versus parental cells post-treatment. FDR = Benjamini-Hochberg False Discovery Rate. In the p53 regulation column, “+”, “-“and “?” correspond to positive, negative, and uncertain regulation by p53, respectively. Red = positive, blue = negative, color intensity corresponds to fold change magnitude. (XLSX 104 kb)

针对经处理后的耐SINE化合物细胞与亲代细胞中全部基因的表达倍数变化开展MetaCore分析（MetaCore）。错误发现率（FDR，Benjamini-Hochberg False Discovery Rate）采用本杰明尼-霍赫贝格法计算，红色代表基因表达上调，蓝色代表基因表达下调，颜色深浅与表达倍数变化的幅度呈正相关。
表S2：针对经处理后的携带有p53调控元件的耐SINE化合物细胞与亲代细胞中相关基因的表达倍数变化开展MetaCore分析。错误发现率（FDR，Benjamini-Hochberg False Discovery Rate）采用本杰明尼-霍赫贝格法计算；在p53调控列中，符号"+"、"-"和"?"分别代表p53对基因的正向调控、负向调控与不确定调控。红色代表基因表达上调，蓝色代表基因表达下调，颜色深浅与表达倍数变化的幅度呈正相关。本数据集为XLSX格式，文件大小104 KB。