Multi-omics investigation of innate navitoclax resistance in triple-negative breast cancer cells

We assessed the effects of navitoclax, on the transcriptome, methylome, chromatin structure, and copy number variation of MDA-MB-231 triple-negative breast cancer cells. Cells were sampled before treatment (S1), at 72 hours of exposure (S2), and after a 10-day drug-free recovery from treatment (S3). MDA-MB-231 cells were grown in two identical parallel experiments (replicates "a" and "b")

本研究评估了纳维托克拉（navitoclax）对MDA-MB-231三阴性乳腺癌细胞的转录组、甲基化组、染色质结构及拷贝数变异的影响。实验分别在给药前（S1）、药物暴露72小时时（S2）以及停药后经10天无药恢复培养后（S3）三个时间点采集细胞样本。本研究通过两组完全一致的平行实验（重复组a与b）培养MDA-MB-231细胞。