Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid

Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid Descriptor: 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one, Aldo-keto reductase family 1 member C3, CHLORIDE ION, ... Authors: Goyal, P, Wahlgren, W.Y, Friemann, R. Deposit date: 2017-12-07 Release date: 2018-04-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem, 150, 2018

基于苯并异恶唑母核的强效选择性醛酮还原酶1C3（Aldo-Keto Reductase 1C3，AKR1C3）抑制剂：生物等排体骨架跃迁策略在氟芬那酸上的应用。表征信息：4-[[3,5-双(三氟甲基)苯基]氨基]-1,2-苯并恶唑-3-酮、醛酮还原酶家族1成员C3、氯离子等。作者：Goyal P、Wahlgren W.Y、Friemann R。提交日期：2017年12月7日；发布日期：2018年4月4日；最后修改日期：2024年1月17日。检测方法：X射线衍射（分辨率1.3埃）。引用文献：基于苯并异恶唑母核的强效选择性醛酮还原酶1C3（AKR1C3）抑制剂：生物等排体骨架跃迁策略在氟芬那酸上的应用。《欧洲药物化学杂志（Eur J Med Chem）》，150卷，2018年。