Kinetic parameters for POLRMT-catalyzed nucleotide incorporation^a.

aValues rounded to two significant figures. Standard errors are from non-linear regression fits of data to a hyperbolic model (Figures S1, S2 and S3). bmitovir score: rate constant for incorporation calculated by using the experimentally determined kinetic parameters, kpol and Kd,app and the intracellular concentration of nucleoside analog triphosphate [TP] (Table 1); mitovir score = keff (s−1) = (kpol * [TP])/(Kd,app+[TP]). cmitovir score determined for Huh-7 cells. dmitovir score determined for MT4 cells. erate constant for incorporation calculated by using the experimentally determined kinetic parameters, kpol and Kd,app and the intracellular concentration of nucleotide [TP] (Table S1); keff (s−1) = (kpol * [TP])/(Kd,app+[TP]). fnot determined.a 数值保留两位有效数字。标准误差来自将数据拟合至双曲线模型的非线性回归分析（补充图S1、S2及S3）。 b mitovir评分（mitovir score）：指通过实验测定的动力学参数kpol、表观解离常数Kd,app，以及核苷类似物三磷酸[TP]的细胞内浓度（表1）计算得到的掺入速率常数；mitovir评分=keff (s⁻¹)=(kpol·[TP])/(Kd,app+[TP])。 c 针对Huh-7细胞测定的mitovir评分。 d 针对MT4细胞测定的mitovir评分。 e 掺入速率常数：通过实验测定的动力学参数kpol、表观解离常数Kd,app，以及核苷酸[TP]的细胞内浓度（补充表S1）计算得到；keff (s⁻¹)=(kpol·[TP])/(Kd,app+[TP])。 f 未测定。