Deciphering styrene oxide tolerance mechanisms in Gluconobacter oxydans mutant strain

Biocatalysis is an important field of green biofabrication, which is widely used in the efficient synthesis of various chemicals. Since the conversion substrate is mostly insoluble, it is necessary to add organic solvents to improve the solubility of the substrate, but the toxic effect of the organic solvents on the microorganisms in the conversion chassis greatly limits the addition amount of the agent, and also limits the conversion system. Therefore, it is urgent to obtain microbial chassis cells that are resistant to organic solvents.

生物催化（Biocatalysis）是绿色生物制造的重要研究领域，已被广泛应用于各类化学品的高效合成。由于多数转化底物不溶于反应介质，需通过添加有机溶剂来提升底物溶解度，但有机溶剂对转化底盘（conversion chassis）内微生物的毒性效应，极大限制了该类试剂的添加量，同时也严重制约了转化体系的整体性能。因此，获取耐有机溶剂的微生物底盘细胞已成为当前亟待突破的关键需求。