Aging larynx

The larynx undergoes significant age and sex-related changes in structure and function across the lifespan. Emerging evidence suggests that laryngeal microbiota influences immunological processes. Thus, there is a critical need to delineate microbial mechanisms that may underlie laryngeal physiological and immunological changes. As a first step, the present study explored potential age- and sex-related changes in the laryngeal microbiota across the lifespan in a murine model.喉部（larynx）在整个生命周期中会出现与年龄和性别相关的显著结构与功能变化。日益增多的研究证据表明，喉部微生物群（laryngeal microbiota）可参与调控免疫过程。因此，亟需阐明可能介导喉部生理与免疫变化的微生物机制。作为本研究的首要步骤，我们通过小鼠模型（murine model）探究了全生命周期内喉部微生物群潜在的年龄与性别相关变化。