Circulating Exosomal miRNA as a Biomarker for Age-Related Cognitive Decline and Decreased Hippocampal Volume

Neural imaging, genetics, and circulating biomarkers are being developed to differentiate normal aging from diseases that affect cognition. The blood based biomarkers, such as plasma exosome could provide a simple and relatively inexpensive means for tracking the progression of cognitive decline and effectiveness of treatments, as well as providing information on mechanism for cognitive impairment. Overall design: The study included 97 human subjects, males (n = 58) and females (n = 39) (age range 44-102 years, average 73 years). Plasma exosomal miRNA was used to investigate the expression level associated with cognitive decline.

目前正研发神经影像、遗传学及循环生物标志物相关技术，旨在区分正常衰老与影响认知功能的疾病。血液源性生物标志物（例如血浆外泌体（plasma exosome））可提供一种简便且成本相对较低的检测手段，用于追踪认知衰退的进展过程、治疗方案的有效性，同时可为认知障碍的发病机制提供相关信息。研究整体设计：本研究共纳入97名受试者，其中男性58例、女性39例，年龄范围为44至102岁，平均年龄73岁。本研究采用血浆外泌体微小RNA（miRNA），探究其表达水平与认知衰退的相关性。