Blood RNA signature RISK4LEP predicts leprosy years before clinical onset

Exploratory RNA expression analysis during development of leprosy allows identification of RISK4LEP, a 4-gene blood RNA signature predicting leprosy years before clinical onset. Comparison of blood transcriptomics in leprosy progressors before symptoms (First), at diagnosis (Second) and household contact controls (HHC)

针对麻风病发病进程开展的探索性RNA表达分析，成功鉴定出RISK4LEP——一种可在临床发病数年前预测麻风病发生的4基因血液RNA特征。本研究对出现症状前（第一组）、确诊时（第二组）的麻风病进展者，以及家庭接触者对照（HHC）的血液转录组进行了比较分析。