Association between sex, age, mGFR, and proteinuria at inclusion and hazard of progression to CKD stage 5 and death.

Abbreviations: CKD, chronic kidney disease; HR, hazard ratio; CI, confidence interval; mGFR, measured glomerular filtration rate; PCR, protein/creatinine ratio.*M1, Weibull model imputing the time to progression to CKD stage 5 at the time at the first mGFR measure below 15 mL/min/1.73 m2, or censoring at death or latest news (n = 1519 patients contributed to the analysis); M2, Weibull model for death before CKD stage 5 diagnosis, censoring at the time at the first mGFR measure below 15 mL/min/1.73 m2 (n = 1519); M3, Weibull model for death after CKD stage 5 diagnosis (n = 245); M4, Weibull illness-death model accounting for interval censoring (n = 1519).Association between sex, age, mGFR, and proteinuria at inclusion and hazard of progression to CKD stage 5 and death.

缩写说明：CKD为慢性肾脏病（chronic kidney disease）；HR为风险比（hazard ratio）；CI为置信区间（confidence interval）；mGFR为实测肾小球滤过率（measured glomerular filtration rate）；PCR为尿蛋白/肌酐比值（protein/creatinine ratio）。*M1：威布尔模型，用于估算首次实测肾小球滤过率低于15 mL/min/1.73 m²时进展至CKD 5期的时间，或以死亡或末次随访数据作为截尾终点（本分析共纳入1519例患者）；*M2：威布尔模型，用于分析CKD 5期确诊前的死亡风险，以首次实测肾小球滤过率低于15 mL/min/1.73 m²的时间作为截尾点（样本量n=1519）；*M3：威布尔模型，用于分析CKD 5期确诊后的死亡风险（样本量n=245）；*M4：考虑区间截尾的威布尔疾病-死亡模型（样本量n=1519）。入组时的性别、年龄、实测肾小球滤过率与蛋白尿水平和进展至CKD 5期的风险及死亡风险之间的相关性。