Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma [atlas]

Medulloblastoma, a malignant childhood cerebellar tumor, molecularly segregates into biologically distinct subgroups warranting personalized therapy. Murine modeling and cross-species genomics have provided mounting evidence of discrete, subgroup-specific developmental origins. Developing murine cerebellum analyzed by scRNAseq.

髓母细胞瘤（Medulloblastoma）是一种儿童恶性小脑肿瘤，可通过分子特征划分为生物学特性迥异的亚型，此类亚型亟需个性化治疗策略。小鼠模型构建与跨物种基因组学研究已积累了大量证据，证实各亚型拥有独立且亚型特异性的发育起源。本数据集通过单细胞RNA测序（scRNAseq）对发育中小鼠小脑组织进行了分析。