Crystal structure of human DNPH1 bound to inhibitor 3a

Crystal structure of human DNPH1 bound to inhibitor 3a Descriptor: 1,2-ETHANEDIOL, 5-hydroxymethyl-dUMP N-hydrolase, PHOSPHORIC ACID MONO-(4-HYDROXY-PYRROLIDIN-3-YLMETHYL) ESTER Authors: Wagner, A.G, Schramm, V.L, Almo, S.C, Ghosh, A. Deposit date: 2024-08-21 Release date: 2025-02-05 Last modified: 2026-05-20 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms. J.Med.Chem., 68, 2025