Haemoglobin and other data from perioperative goal directed fluid protocols in total knee arthroplasty surgery patients (RCT)

We prospectively studied patients undergoing total knee arthroplasty (TKA). As part of a revised GDT (revGDT) protocol, the mini volume loading test (mVLT) was applied before induction of anaesthesia and surgery (pre-operative) and also 24-h later (post-operative). The mVLT implies mini fluid challenges consisting of acetated Ringer’s boluses followed by 5-min periods without fluids. Three 5 mL kg^-1 boluses were used in mVLT for 36 TKA patients, and six 2.5 mL kg^-1 boluses in other 48 TKA patients. Haemoglobins - invasive (aHb, arterial; and vHb, venous) and non-invasive (SpHb, capillary), as well as stroke volume (SV) deviation from baseline (%), perfusion index (PI) and its deviation from baseline (PID), mean arterial pressure (MAP). They were measured before and after each mini fluid challenge and also 20 min after the last bolus. We present our records of raw data. Several variables were obtained by mathematically processing haemoglobin values: plasma dilution (PD), plasma dilution efficacy (PDE), arterio-capillary plasma dilution efficacy difference (acPED) as well as relative difference between the paired invasive and non-invasive haemoglobin measurements (RD) and absolute RD (ARD) and some other parameters. We post the related math.

本研究前瞻性纳入接受全膝关节置换术（total knee arthroplasty, TKA）的患者。作为修订版目标导向液体治疗（revised GDT, revGDT）方案的组成部分，迷你容量负荷试验（mini volume loading test, mVLT）分别于麻醉及手术诱导前（术前）与术后24小时实施。该迷你容量负荷试验由迷你液体冲击试验组成：先给予醋酸林格液推注，随后暂停补液5分钟。36例TKA患者的mVLT采用3次5 mL·kg⁻¹的推注剂量，其余48例TKA患者则采用6次2.5 mL·kg⁻¹的推注剂量。本研究监测的指标包括有创动脉血红蛋白（arterial haemoglobin, aHb）、有创静脉血红蛋白（venous haemoglobin, vHb）以及无创毛细血管血红蛋白（SpHb, capillary）；此外还包括每搏输出量（stroke volume, SV）相对于基线的偏差百分比、灌注指数（perfusion index, PI）及其相对于基线的偏差（PID），以及平均动脉压（mean arterial pressure, MAP）。上述指标均在每次迷你液体冲击试验前后以及末次推注后20分钟时进行测量。本研究公开了原始数据记录。通过对血红蛋白数值进行数学处理，可得到多项衍生变量：血浆稀释度（plasma dilution, PD）、血浆稀释效能（plasma dilution efficacy, PDE）、动-毛细血管血浆稀释效能差（arterio-capillary plasma dilution efficacy difference, acPED），以及配对有创与无创血红蛋白测量值的相对差值（RD）、绝对相对差值（ARD）与其他若干参数。本研究同时公开了相关数学计算公式。