SARS-CoV-2-host interactions

Coronaviruses are a group of enveloped viruses with single‑stranded, positive‑sense RNA genomes. Each of the steps of viral replication - attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release - involves host factors. These interactions can cause alterations in cellular structure and physiology, and activate host stress responses, autophagy, cell death, and processes of innate immunity (Fung TS & Liu DX 2019). This Reactome module describes molecular mechanisms by which severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) modulates innate and adaptive immune responses, autophagy, host translation, intracellular signaling and regulatory pathways, and PDZ-mediated cell-cell junctions, mostly annotated from studies of cells infected with SARS-CoV-2.

冠状病毒是一类包膜病毒，具有单链正链RNA基因组。病毒复制的各个阶段——包括附着与进入、病毒复制酶的翻译、基因组转录与复制、结构蛋白的翻译、病毒颗粒的组装与释放——均涉及宿主因子。这些相互作用可能导致细胞结构和生理功能的改变，并激活宿主的应激反应、自噬、细胞凋亡以及先天免疫过程（Fung TS & Liu DX 2019）。本Reactome模块描述了严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）通过何种分子机制调节先天性和适应性免疫反应、自噬、宿主翻译、细胞内信号传导和调控途径，以及PDZ介导的细胞间连接，主要源自对感染SARS-CoV-2的细胞的研究。