RNA-seq dataset for MPNST patient tissue samples. RNA-seq dataset for MPNST patient tissue samples

Comprehensive transcriptomic profiling of PRC2 mutant MPNST patient tissues with adjacent normal tissues and neurofibroma patient tissues was performed to investigate gain of specific transcriptional signature associated with PRC2 loss during transformation to MPNST. Overall design: There are 17 samples with 7 tumor samples, 7 adjacent normal samples and 3 neurofibroma samples.

本研究对多梳蛋白抑制复合体2（Polycomb Repressive Complex 2, PRC2）突变型恶性周围神经鞘膜瘤（Malignant Peripheral Nerve Sheath Tumor, MPNST）患者的肿瘤组织、正常毗邻组织及神经纤维瘤（Neurofibroma）患者组织开展全面转录组表达谱分析，旨在探究向MPNST转化过程中，与PRC2缺失相关的特异性转录特征的获得机制。实验设计：本次研究共纳入17例样本，其中包含7例肿瘤样本、7例正常毗邻组织样本与3例神经纤维瘤样本。