Dice

2014年建立的DICE (免疫细胞表达数据库，表达数量性状基因座 (eqtl) 和表观基因组学) 项目旨在通过 (i) 在健康受试者的人类免疫细胞类型中生成参考转录组和表观基因组图谱，(ii) 鉴定影响免疫细胞中基因表达 (eqtl和染色质qtl) 的功能性单核苷酸多态性 (snp)，以及 (iii) 鉴定与人类疾病发展有关的调控机制和新的靶基因。我们还在研究常见遗传变异的细胞类型特异性作用以及性别对免疫细胞基因表达的影响。这些数据集将有助于揭示与疾病风险相关的遗传多态性对特定免疫细胞类型的影响，从而提供有关它们如何影响发病机理的机制见解。

The DICE (Database of Immune Cell Expression, Expression Quantitative Trait Loci (eQTLs), and Epigenomics) project was established in 2014. Its core objectives include: (i) generating reference transcriptomic and epigenomic atlases across human immune cell types from healthy donors; (ii) identifying functional single nucleotide polymorphisms (SNPs) that regulate gene expression in immune cells, including eQTLs and chromatin QTLs; and (iii) uncovering regulatory mechanisms and novel target genes linked to human disease development. Additionally, the project investigates the cell type-specific effects of common genetic variants, as well as the impact of sex on gene expression in immune cells. These datasets will aid in elucidating how disease risk-associated genetic polymorphisms influence specific immune cell populations, providing mechanistic insights into their contributions to disease pathogenesis.