LOH and copy neutral LOH (Uniparental Disomy) events.

A: Segmental UPD events spanning multiple microRNA regions in chromosome 4 in patient 9F. B: LOH event in chromosome 17 of the same sample above. LOH is associated with copy number variations. C: Target Prediction analysis of miRNAs exhibit the probable involvement of known signaling pathways in colorectal cancer. Y-axis represents the numerical score indicative of predictive value. D: TPM3 and MUC1 are affected by UPD events in patient 7F. E: MYC region sustain LOH events and copy gains in patient 10F.A: 患者9F的4号染色体上跨越多个微小RNA（microRNA）区域的节段性单亲二体（Uniparental Disomy, UPD）事件。B: 上述同一样本的17号染色体上的杂合性丢失（Loss of Heterozygosity, LOH）事件。杂合性丢失与拷贝数变异（copy number variations）相关。C: 针对微小RNA的靶标预测分析显示，结直肠癌中已知信号通路或存在相关参与作用，纵轴代表反映预测价值的数值评分。D: 原肌球蛋白3（TPM3）与黏蛋白1（MUC1）在患者7F中受单亲二体事件影响。E: MYC基因区域在患者10F中存在杂合性丢失事件与拷贝数扩增现象。