Fatty Acid Mimetic with Multi-Specific Actions Inhibits Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease

The peroxisome proliferator-activated receptors (PPARs) are transcription factors that regulate glucose and lipid homeostasis. Activation of PPARs has been explored for the treatment of type 2 diabetes and dyslipidemia. LDT409 is a novel fatty acid like compound that has been shown to be a pan-active PPAR agonist. This data explores the changes in the liver proteome of mice treated with LDT409 while fed either a chow or high fat diet.

过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptors, PPARs）是一类调控糖脂稳态的转录因子。PPARs的激活已被探索用于治疗2型糖尿病与血脂异常。LDT409是一种新型脂肪酸类化合物，被证实为泛活性PPAR激动剂。本数据集探究了分别饲喂普通饲料与高脂饮食的小鼠经LDT409处理后，其肝脏蛋白质组的变化情况。