<b>HISTOLOGICAL STUDIES OF THE </b><b>EFFECT</b><b> </b><b>OF EXCESSIVE ALCOHOL</b><b> </b><b>CONSUMPTION ON THE LIVER OF WISTAR RATS</b>

The excessive consumption of alcohol poses a significant public health concern due to its detrimental effects on individual well-being, particularly on the liver. Chronic ethanol ingestion leads to morphological and functional alterations in the liver, affecting hepatic cells, thus impairing it's functions. In this study, we carefully investigated the impact of chronic ethanol consumption on liver histological morphology.Animals were divided into 4 groups in number of 5 (n=5), the control (water), group 2 1ml of 17% alcohol (10g/kg/b.w. p.o), group 3 were given 3mls of 17% alcohol, and group 4 were given 5mls of 17% alcohol, with 5 animals in each. Over 30 days, ethanol consumption was monitored ad libitum.Results revealed chronic inflammatory pattern, deterioration of hepatic structures, mild interstitial congestion and inflammation. This study underscores the importance of understanding the pathological effects of alcohol on the liver and emphasizes the need for interventions to mitigate its impact on public health.过量饮酒因其对个体健康，尤其是肝脏的损害作用，已成为一项严峻的公共卫生问题。长期乙醇摄入会引发肝脏的形态与功能改变，影响肝细胞，进而损害肝脏的正常功能。本研究针对长期乙醇摄入对肝脏组织学形态的影响展开了细致探究。实验将动物分为4组，每组5只（n=5）：对照组给予纯水，第2组给予1mL 17%乙醇溶液（剂量为10g/kg/体重，经口灌胃），第3组给予3mL 17%乙醇溶液，第4组给予5mL 17%乙醇溶液，各组均包含5只动物。实验周期为30天，乙醇摄入全程采用自由饮用（ad libitum）方式。实验结果显示，受试动物呈现慢性炎症特征、肝脏结构退化，以及轻度间质充血与炎症反应。本研究凸显了深入理解酒精对肝脏病理损伤机制的重要性，并强调需采取干预措施以减轻其对公共卫生造成的负面影响。