Effects of Lactiplantibacillus plantarum VB165 on gut microbiota of Insulin-Resistant Mice

This study investigated the effects of Lactiplantibacillus plantarum VB165, a probiotic strain with intrinsic Alpha glucosidase inhibitor (AGI) activity, on metabolic disorders in high-fat diet (HFD)-induced insulin-resistant (IR) mice. L. plantarum VB165 improves HFD-induced metabolic disorders via multi-target mechanisms, modulated gut microbiota community composition, suppressing HFD-enriched genera and promoting beneficial taxa.

本研究探究了具有内源性α-葡萄糖苷酶抑制剂（Alpha glucosidase inhibitor，AGI）活性的益生菌菌株植物乳杆菌（Lactiplantibacillus plantarum）VB165，对高脂饮食（high-fat diet，HFD）诱导的胰岛素抵抗（insulin-resistant，IR）小鼠代谢紊乱的改善效果。植物乳杆菌VB165可通过多靶点机制改善高脂饮食诱导的代谢紊乱，具体表现为调控肠道菌群群落组成，抑制高脂饮食富集的菌属，并促进有益菌群类群的增殖。