Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift. Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

To investigate the differential genes expression between young and aged Lgr5 high-ISCs We performed single-cell gene expression profiling analysis using data obtained from 3 young and 4 old mice Overall design: Comparative gene expression profiling analysis of sc-RNA-seq data for young and aged Lgr5 high-ISCs from young and aged mice

为探究年轻与衰老的Lgr5高阳性肠干细胞（Lgr5 high-Intestinal Stem Cells, Lgr5 high-ISCs）之间的差异基因表达模式，我们采用3只年轻小鼠与4只老年小鼠获得的测序数据，开展了单细胞基因表达谱分析。整体实验设计：针对源自年轻与衰老小鼠的Lgr5高阳性肠干细胞的单细胞RNA测序（single-cell RNA sequencing, sc-RNA-seq）数据，开展对比基因表达谱分析。