Epigenetic subtypes of neuroblastoma [SK-N-BE(2)-C Ectopic HRASV12 induction]

In the absence of recurrent gene mutations, evidence accumulates that epigenetic deregulation plays a prominent role in neuroblastoma biology. Here we provide single cell expression profiles (scRNA-seq 10x Genomics) of SK-N-BE(2)-C cells after induction of mutant HRASV12 single-cell RNA-seq in SK-N-BE(2)-C cell line after ectopic induction of mutant HRASV12 and control

在未发生复发性基因突变的背景下，越来越多的研究证据表明，表观遗传失调在神经母细胞瘤的生物学过程中扮演着核心角色。本研究提供了基于10x Genomics平台的单细胞RNA测序（single-cell RNA-seq，简称scRNA-seq）所获得的SK-N-BE(2)-C细胞系的单细胞表达谱数据，涵盖异位诱导突变型HRASV12后的细胞样本与对应的对照组样本。