遇见数据集

Naturally occurring and synthetic nucleosome-positioning or nucleosome-repelling sequences used in this study.

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Figshare2015-12-02 更新2026-04-29 收录
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The sequences described here were chosen because each has been found to have significant effects on in vivo nucleosome positions and/or in vitro nucleosome affinities, as shown in the rightmost column. The exception is the GC-rich sequence from humans: although its nucleosome affinity has not been directly determined either in vivo or in vitro, it is predicted to correlate with high nucleosome occupancy because of its high G+C content [17] and is occupied by a nucleosome(s) in vivo according to micrococcal nuclease digestion [22]. Two-letter abbreviations given in parentheses under each full sequence name will be used in figure legends in the rest of this work.

本研究选用的序列均已被证实可对体内(in vivo)核小体(nucleosome)定位及/或体外(in vitro)核小体结合亲和力产生显著影响,具体如最右侧列所示。 唯一例外为人类来源的富GC序列:尽管其核小体结合亲和力尚未通过体内或体外实验直接测定,但鉴于其较高的G+C碱基含量[17],该序列被预测与高核小体占据率相关;同时根据微球菌核酸酶(micrococcal nuclease)消化实验的相关结果[22],该序列在体内存在核小体占据现象。 每个完整序列名称下方括号内标注的双字母缩写,将在本文后续部分的图例中使用。

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2015-12-02
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