cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation

This data provides evidence that elevation of cAMP levels has a dramatic effect on the transcriptome of yeast cells, with particular emphasis on mitochondrial function and the promotion of ROS production S. cerevisiae cells lacking the high affinity phosphodiesterase PDE2or both PDE2 and the PKA subunit TPK3 were grown for 24h in rich media in the presence of 4mM exogensously added cAMP. 8 samples.

本数据集提供了如下证据：环腺苷酸（cAMP）水平升高会对酵母细胞的转录组产生显著影响，其中尤其聚焦于线粒体功能以及活性氧（ROS）生成的促进过程。本研究将缺失高亲和力磷酸二酯酶PDE2，或同时缺失PDE2与蛋白激酶A（PKA）亚基TPK3的酿酒酵母（S. cerevisiae）细胞置于添加了4mM外源cAMP的富营养培养基中培养24小时，共计8个样本。