Continuous-trait probabilistic model for comparing multi-species functional genomic data

We developed a probabilistic method to simultaneously infer genome-wide heterogeneous evolutionary states. We applied the proposed method to analyze a cross-species DNA replication timing (RT) dataset from the same cell type in five primate species. We demonstrated that the proposed model enables discovery of genomic regions with distinct evolutionary patterns of RT. Overall design: Comparing replication timing profile among 5 primate species本研究开发了一种概率方法，可同时推断全基因组范围内的异质性演化状态。我们将所提出的方法应用于分析来自5种灵长类动物同一细胞类型的跨物种DNA复制时序（DNA replication timing, RT）数据集。本研究证明，所提出的模型可用于发现具有独特DNA复制时序演化模式的基因组区域。研究设计概述：对5种灵长类动物的复制时序谱进行比较分析。