Spatial transcriptomics reveals organizational properties of mouse spinal cord and alterations in neuropathic pain

Abstract

The spinal cord integrates diverse somatosensory inputs and executes motor outputs through anatomically and functionally distinct circuits. Here, we employed spatially resolved single-cell transcriptomic profiling of the adult mouse spinal cord to gain insights into the organizational logic of the spinal cord during health and neuropathic pain. This spatially resolved cellular and molecular map of the spinal cord will facilitate the decoding of circuit mechanisms underlying somatosensory and motor functions in health and disease.

摘要
脊髓可整合多种躯体感觉输入（somatosensory inputs），并通过解剖结构与功能均存在差异的神经环路执行运动输出（motor outputs）。本研究针对成年小鼠脊髓开展空间分辨单细胞转录组分析（spatially resolved single-cell transcriptomic profiling），以阐明健康与神经病理性疼痛（neuropathic pain）状态下脊髓的组织逻辑。这份脊髓的空间分辨细胞与分子图谱，将助力解码健康及疾病状态下躯体感觉与运动功能背后的环路机制。