Additional file 1 of ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans

Additional file 1: Figure S1. Similar Rn7sk expression in WT and KO NPCs according to RNA-seq.  Table S1. Detailed parameters of differentially expressed transcripts in WT versus KO NPCs according to RNA-seq.  Table S2. GO analysis of significantly dysregulated genes in terms of biological process. Table S3. Genes with highly different Pol II peak density (FDR<0.1) between WT and KO NPCs. Table S4. RT-qPCR primer sequences.  Uncropped blots.

附加文件1：补充图S1。基于RNA测序（RNA-seq）的野生型（Wild Type, WT）与敲除型（Knock Out, KO）神经前体细胞（Neural Progenitor Cells, NPC）中Rn7sk的表达水平相似。 补充表S1。基于RNA测序的野生型与敲除型神经前体细胞间差异表达转录本的详细参数。 补充表S2。针对生物过程分类的显著差异表达基因的基因本体（Gene Ontology, GO）分析。 补充表S3。野生型与敲除型神经前体细胞间RNA聚合酶II（RNA Polymerase II, Pol II）峰密度存在显著差异（错误发现率False Discovery Rate, FDR<0.1）的基因。 补充表S4。实时定量聚合酶链式反应（RT-qPCR）引物序列。 未裁剪的免疫印迹原图。