Transcriptome-wide discovery of microRNA binding sites in human brain by Ago2 HITS-CLIP (CLIP-Seq). Homo sapiens

Here, seeking to gain insight into the array of transcripts engaged with miRNAs in human brain, we performed HITS-CLIP to profile transcriptome-wide Ago2:RNA interactions in a panel of eleven post-mortem adult human brain samples harvested from adult motor cortex and cingulate gyrus, regions associated with movement and psychiatric disorders .

本研究旨在探究人类大脑中与微小RNA（miRNAs）结合的各类转录本，遂采用HITS-CLIP技术，对11份取自成人运动皮层与扣带回的尸检成人脑组织样本开展转录组范围的Ago2蛋白-RNA相互作用谱分析；上述脑区与运动障碍及精神疾病的发生密切相关。