Differences of genomic profiles between NSCLC patients with and without osseous metastasis

In this study, we carried out targeted next-generation sequencing (NGS) of tumor tissues from NSCLC patients by a hybridization capture-based panel. The differences in somatic mutations, somatic interactions, key signaling pathways, functional biological information, and clinical actionability for the therapy of targeted agents were explored between advanced patients with and without osseous metastasis.

本研究采用基于杂交捕获的测序Panel，对非小细胞肺癌（NSCLC）患者的肿瘤组织开展靶向下一代测序（NGS）。本研究探究了伴骨转移与无骨转移的晚期非小细胞肺癌患者在体细胞突变、体细胞互作、关键信号通路、功能生物学信息以及靶向药物治疗的临床可指导性方面的差异。