Global Surveillance of Candida albicans: MIC Distributions, Resistance Patterns, and Temporal Trends from the ATLAS Program (2015–2024)

This study presents a comprehensive decade-long analysis of 6,342 <i>Candida albicans</i> isolates collected across 41 countries as part of the ATLAS global surveillance program. To our knowledge, this represents one of the largest and most geographically diverse datasets evaluating antifungal susceptibility trends in <i>C. albicans</i>. Our findings confirm the continued efficacy of echinocandins and amphotericin B but reveal early, measurable shifts in azole susceptibility and the emergence of geographically confined resistance clusters—particularly in southern Europe and East Asia. These observations carry significant implications for antifungal stewardship, regional treatment policy, and early resistance detection.

本研究针对作为ATLAS全球监测计划组成部分、收集自41个国家的6342株白假丝酵母（Candida albicans）分离株，开展了为期十年的综合分析。据我们所知，本数据集是目前针对白假丝酵母抗真菌药物敏感性趋势开展评估的规模最大、地理覆盖最广泛的数据集之一。本研究结果证实，棘白菌素类与两性霉素B仍持续保有良好的抗真菌活性，但同时也揭示出唑类药物敏感性出现了早期可观测到的变化，以及地理限制性耐药簇的出现——尤其在南欧与东亚地区。上述发现对抗真菌药物管理、区域性治疗政策制定以及耐药性早期监测均具有重要指导价值。