Three-Component Coupling Reaction Triggered by Insertion of Arynes into the SO Bond of DMSO

An unprecedented three-component
coupling reaction of arynes, α-bromo
carbonyl compounds, and DMSO triggered by insertion of arynes into
the SO bond of DMSO has been developed. The reaction can generate
a wide range of multi­substituted aryl methyl thioethers in good
yields, wherein DMSO serves as both methyl­thiolation reagent
and oxygen source.

本研究开发了一种前所未有的三组分偶联反应，该反应以芳炔（arynes）、α-溴代羰基化合物（α-bromo carbonyl compounds）与二甲基亚砜（DMSO）为底物，其触发机制为芳炔插入二甲基亚砜的S=O键。该反应可获得良好收率，合成一系列多取代芳基甲基硫醚，且二甲基亚砜在反应中同时充当甲基硫醇化试剂与氧源。