Ruthenium-Catalyzed Highly Regioselective Cyclization of Ketoximes with Alkynes by C–H Bond Activation: A Practical Route to Synthesize Substituted Isoquinolines

Aromatic and heteroaromatic ketoximes underwent cyclization with alkynes in the presence of a catalytic amount of [{RuCl2(p-cymene)}2] and NaOAc to give isoquinoline derivatives in good to excellent yields in a highly regioselective manner.

芳香族与杂芳族酮肟在催化量的二氯(对伞花烃)合钌(II)二聚体([{RuCl₂(p-cymene)}₂])及乙酸钠(NaOAc)的作用下，与炔烃发生环化反应，以良好至优异的产率、高度区域选择性地得到异喹啉衍生物。