Tdap maternal immunization and infant follow-up trials: Immunogenicity, transplacental transfer of pertussis antibodies, safety following pertussis immunization during pregnancy and its impact on infant pertussis immune response

This video supports the two published articles by KP Perrett, et al. Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controlled trial. Vaccine. 2020;38(8):2095-2104, and KP Perrett, et al. Impact of tetanus-diphtheria-acellular pertussis immunization during pregnancy on subsequent infant immunization seroresponses: follow-up from a large randomized placebo-controlled trial. Vaccine. 2020;38(8):2105-2114.

These articles describe the results of two clinical trials, respectively.
First study - a maternal immunization trial which assessed the safety and immunogenicity of a reduced antigen content diphtheria-tetanus-acellular pertussis (Tdap) vaccination during pregnancy, as well as the transfer of maternal pertussis antibodies through the umbilical cord.
Second study - an infant follow-up study which assessed the safety and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus and Haemophilus influenza type B vaccine (DTPa-HBV-IPV/Hib) when administered to healthy infants born to mothers vaccinated in the maternal immunization trial.

本视频数据集附属于KP Perrett等人发表的两篇学术论文：其一为《妊娠期接种百日咳疫苗后的免疫原性、百日咳抗体经胎盘转运及安全性：一项随机安慰剂对照试验的证据》，刊载于《疫苗（Vaccine）》2020年；38(8):2095-2104；其二为《妊娠期接种破伤风-白喉-无细胞百日咳疫苗对后续婴儿疫苗接种血清应答的影响：一项大型随机安慰剂对照试验的随访研究》，刊载于《疫苗（Vaccine）》2020年；38(8):2105-2114。上述两篇论文分别阐述了两项临床试验的研究结果。第一项研究为母体免疫试验，旨在评估妊娠期接种减少抗原含量的白喉-破伤风-无细胞百日咳（Tdap）疫苗的安全性与免疫原性，以及母体百日咳抗体经脐带的转运情况。第二项研究为婴儿随访研究，旨在评估在上述母体免疫试验中接受疫苗接种的母亲所诞下的健康婴儿，接种白喉-破伤风-无细胞百日咳-乙型肝炎-灭活脊髓灰质炎病毒及b型流感嗜血杆菌联合疫苗（DTPa-HBV-IPV/Hib）后的安全性与免疫原性。