Intracranial aneurysm genome-wide association study summary statistics 2020

Summary statistics of a genome-wide association study of intracranial aneurysms in 10,754 cases and 306,882 controls.
Dataset described in: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Bakker, M.K. et alNature Genetics, 16 November 2020doi: 10.1038/s41588-020-00725-7https://www.nature.com/articles/s41588-020-00725-7

The study consisted of 2 stages. Stage 1: European ancestry only. Stage 2: European and East Asian ancestry.Extra files:-Association statistics of the East Asian subset only.-Association statistics of only aneurysmal subarachnoid hemorrhage versus controls-Association statistics of only unruptured intracranial aneurysms versus controls-Association statistics excluding the UK Biobank (4 files): Stage 1 excluding UK Biobank, Stage 2 excluding UK Biobank, European-only aSAH-only excluding UK Biobank, and cross-ancestry aSAH-only excluding UK Biobank.
Please check the Data Access Policy for further information regarding data use, access and options for additional analyses.

本数据集为纳入10754例病例与306882例对照的颅内动脉瘤（intracranial aneurysms）全基因组关联研究（genome-wide association study）的汇总统计数据。
本数据集相关研究论文为《颅内动脉瘤全基因组关联研究鉴定出17个风险位点（risk loci）并揭示其与临床风险因子的遗传重叠》（Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors），作者为Bakker, M.K. 等，发表于《自然·遗传学》（Nature Genetics）2020年11月16日，DOI: 10.1038/s41588-020-00725-7，原文链接：https://www.nature.com/articles/s41588-020-00725-7。
本研究分为两个阶段：阶段1仅纳入欧洲血统人群；阶段2纳入欧洲及东亚血统人群。
附加文件包括：
1. 仅东亚亚群的关联统计数据；
2. 仅动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhage, aSAH）与对照的关联统计数据；
3. 仅未破裂颅内动脉瘤（unruptured intracranial aneurysms）与对照的关联统计数据；
4. 排除英国生物库（UK Biobank）的关联统计数据集（共4份）：排除英国生物库的阶段1数据、排除英国生物库的阶段2数据、仅欧洲血统且仅aSAH且排除英国生物库的数据，以及跨血统且仅aSAH且排除英国生物库的数据。
如需了解更多关于数据使用、数据访问及额外分析选项的相关信息，请查阅《数据访问政策》（Data Access Policy）。