Serum 25-hydroxyvitamin D concentrations by prognostic characteristics in premenopausal and postmenopausal women diagnosed with breast cancer.

1Two patients with tumor stage not evaluable (TX) were excluded from analysis of stage. For the analysis of histologic grade, ER status and molecular subtype, women with carcinoma in situ (n = 86) were excluded. The numbers do not add up to the total due to missing data: histologic grade (missing n = 22 or 4%), ER status (missing n = 6 or 1%), and molecular subtype (missing n = 8 or 2%).
2Least square mean and standard error (se) were adjusted for age, season of blood collection, and body mass index in linear regression models. Additional adjustment for physical activity did not significantly change the results (data not shown).

1. 2例肿瘤分期不可评估（TX）的患者被排除于肿瘤分期分析之外。针对组织学分级、雌激素受体（Estrogen Receptor，ER）状态与分子亚型的分析，则剔除了86例原位癌（carcinoma in situ）女性患者。由于存在缺失数据，各亚组样本量之和与总例数无法完全匹配：组织学分级缺失22例（占比4%），雌激素受体状态缺失6例（占比1%），分子亚型缺失8例（占比2%）。
2. 在线性回归模型中，我们以年龄、采血季节及体重指数为协变量，对最小二乘均值（Least square mean）与标准误（standard error，se）进行了校正。进一步校正体力活动变量后，分析结果未发生显著改变（数据未展示）。