Data from: Facile fabrication of microfluidic surface-enhanced raman scattering devices via lift-up lithography

We describe a facile and low-cost approach for flexible integration surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by electrostatic assembly of gold nanoparticles, and shaped into designed patterns by the subsequent lift-up soft lithography. The SERS micropattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allows one to ultrasensitively in-situ SERS monitor from the transparent glass window. With its advantages in simplicity, functionality, and cost-effectivity, this method can be readily expanded in optical microfluidic fabrication for biochemical applications.

本文提出一种简便低成本的方法，可将表面增强拉曼散射（surface-enhanced Raman scattering, SERS）基底灵活集成于微流控芯片中。具体而言，该方法通过静电组装金纳米颗粒制备SERS基底，并通过后续的抬升式软光刻（lift-up soft lithography）工艺将其加工为预设图案。所得SERS微图案可便捷地集成至微流道内部。所制备的微流控SERS芯片可通过透明玻璃窗口实现超高灵敏度的原位SERS监测。该方法凭借简便性、功能性与成本效益优势，可轻松推广至面向生化应用的光学微流控制备领域。