RNAseq analyses on copper-dependent gene expression in Streptomyces spp.

Availability of copper ion is crucial for various biological functions. In Streptomyces, a gram-positive soil-dwelling filamentous bacteria, presence of a few micro-molar of copper ion stimulates various phenotypic expression including cell morphogenesis and secondary metabolite production. This project aims at identifying Streptomyces genes whose expression is controlled in a copper-dependent manner.

铜离子的生物可获得性对诸多生物学功能至关重要。在链霉菌（Streptomyces）——一类革兰氏阳性（gram-positive）的土壤栖息丝状细菌——中，几微摩尔浓度的铜离子即可诱导其产生多种表型表达，包括细胞形态发生与次级代谢产物（secondary metabolite）的合成。本项目旨在鉴定表达受铜离子依赖性调控的链霉菌基因。