mRNA profiling in HIV-1 latently infected cells

Investigation of whole genome gene expression level changes in HIV-1 latented infected cells, compared to the replicated cells and control cells. In this study, the in vitro steady cell culture was used to explore the mRNA transcription signatures in HIV-1 infection. mRNA profiles were performed and compared among normal control,HIV-1 latency and HIV-1 replication .

本研究针对HIV-1潜伏感染细胞、复制型感染细胞与对照细胞的全基因组基因表达水平变化展开分析。本研究采用体外稳定细胞培养体系，探究HIV-1感染过程中的mRNA转录特征，并通过构建mRNA表达谱，对正常对照、HIV-1潜伏感染组与HIV-1复制感染组的样本进行对比分析。