French population exposure to Endocrine disruptors in and on plant foodstuffs

The folder "Tables" contains: 7 files to analyze an article sent, to Food Chemistry: Endocrine disruptors on and in fruits and vegetables. Estimation of the potential exposure of the French population (1) French PPP-ED: is an Excel file that gathers, in Table 1, Plant Protection Products (PPP) authorised in France, their usage and applications (foodstuffs), as well as their endocrine disrupting effect if any. A tab contains all the references. (2) French PPP usage-ED: is an Excel file with 4 tables with PPP acting as Endocrine Disruptors (ED). The tables contain the total number of formulas used on 64 fruits and vegetables and the total number of formulas used for the same usage and application. The 4 tables are: Table 2 for Insecticides and acaricides, Table 3: fungicides, Table 4: herbicides, Table 5: growth substances. (3) Exposure calculation-ED: is an Excel file containing Table 7. It gathers data on the 70 PPP acting as ED, on the 64 fruits and vegetables eaten in France. The table calculates daily exposures to ED-PPP from the annual consumption of each foodstuff, the consumption per capita (French population fixed at 64 million citizens). The PPP doses are specific Maximum Residue Limits multiplied by a popularity factor considering the number of formulas that contain the PPP of use, to the total number of formulas used for the same application (same usage, same plant) (4) Exposure summary-ED: is an Excel file containing Table 8. This table gathers the calculated exposure to each PPP-ED, sorted by their type of effect (estrogen Pro and Anti; Androgen: Pro and Anti; thyroid effect: Pro and Anti and "Others"). The sum for each effect is given. (5) Phyto-Product-Enquiry-ED: is an Excel file (Table 6) gathering products recorded in different food categories on French supermarket and websites (March 2020). For all products are site of purchase, URL in March 2020, trademarks, French names, and ingredients. The last tab gives a summary of data with a graphic representation. (6) Genistein + Daidzein values-ED: is an excel file (Table 9) gathering measurements of genistein + daidzein in 140 soy-based foodstuffs and the mean of measurements for several food categories for exposure calculations. (7) Table for comparisons: is an excel file (Table 10) gathering in vitro + in vivo data on hormones, natural and anthropogenic EDs. NOAEL + LOAEL usually obtained in rat, are given next to the putative exposure. References are in next tab. The folder "Figures" contains: Figure 1: Representation of the data sorting procedure for PPP analysis. Data are from the European Union pesticide database. (https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/public/?event=homepage&language=EN accessed in March 2020) Figure 2: Mean isoflavones content (genistein + daidzein) in different food categories found in French supermarket Figure 3: Exposure data obtained previously via an inquiry on French premenopausal women (Lee et al., 2019)

文件夹「Tables」包含7份文件，用于分析投递至《食品化学》（*Food Chemistry*）的论文《果蔬内外的内分泌干扰物：法国人群潜在暴露量估算》：
1. **French PPP-ED**：为Excel文件，其表1收录了在法国获批的植物保护产品（Plant Protection Products, PPP）、其适用场景与对应食品原料，以及对应的内分泌干扰效应（如存在）。该文件的一个工作表包含所有参考文献。
2. **French PPP usage-ED**：为包含4张表格的Excel文件，涉及作为内分泌干扰物（Endocrine Disruptors, ED）的PPP。四张表格分别统计了64种果蔬上使用的制剂总数量，以及同一用途与适用场景下使用的制剂总数量，具体如下：表2（杀虫剂与杀螨剂）、表3（杀菌剂）、表4（除草剂）、表5（生长调节物质）。
3. **Exposure calculation-ED**：为包含表7的Excel文件，收录了70种作为ED的PPP以及法国民众日常食用的64种果蔬的相关数据。该表格基于每种食品的年消费量与人均消费量（法国人口固定为6400万），计算了ED-PPP的每日暴露量。PPP的剂量采用特定的最大残留限量（Maximum Residue Limits, MRLs），并乘以一个应用占比系数：该系数考量了含有目标PPP的制剂数量，占同一适用场景（相同用途、相同作物）下所有使用制剂总数的比例。
4. **Exposure summary-ED**：为包含表8的Excel文件。该表格汇总了每种PPP-ED的计算暴露量，并按效应类型分类（雌激素激动剂与拮抗剂；雄激素激动剂与拮抗剂；甲状腺效应激动剂与拮抗剂，以及「其他」类别），同时给出了每类效应的总暴露量。
5. **Phyto-Product-Enquiry-ED**：为包含表6的Excel文件，收录了2020年3月法国超市与电商平台上架的不同食品类别中的产品信息，具体包括购买渠道、2020年3月的对应URL、商标、法语名称与成分。该文件的最后一个工作表提供了数据汇总，并配有图形展示。
6. **Genistein + Daidzein values-ED**：为包含表9的Excel文件，收录了140种大豆基食品中染料木素（genistein）与大豆苷元（daidzein）的检测值，以及多个食品类别的均值数据，用于暴露量计算。
7. **对比用表格**：为包含表10的Excel文件，收录了关于天然与人为内分泌干扰物的体外（in vitro）与体内（in vivo）激素相关数据。表格同时给出了通常在大鼠实验中获得的未观察到有害作用水平（No Observed Adverse Effect Level, NOAEL）与观察到有害作用的最低水平（Lowest Observed Adverse Effect Level, LOAEL），以及对应的估算暴露量。参考文献位于下一个工作表。

文件夹「Figures」包含以下内容：
图1：PPP分析的数据筛选流程示意图，数据来源于欧盟农药数据库（https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/public/?event=homepage&language=EN，2020年3月访问）
图2：法国超市在售不同食品类别的平均异黄酮含量（染料木素+大豆苷元）
图3：此前通过对法国绝经前女性开展的问卷调查获得的暴露数据（Lee et al., 2019）