Transcriptional modulation of Quoring-sensing signaling throught QslA in Pseudomonas aeruginosa PA14 and PAO1.. Transcriptional modulation of Quoring-sensing signaling throught QslA in Pseudomonas aeruginosa PA14 and PAO1.

To further determine the origin of the increased virulence of Pseudomonas aeruginosa PA14 compared to Pseudomonas aeruginosa PAO1, we report a transcriptomic approach through RNA sequencing. Next-generation sequencing (NGS) has revolutioned sistems-based analsis of transcriptomic pathways. The goals of this study are to compare the transcriptomic profile of all 5263 orthologous genes of these nearly two strains of Pseudomonas aeruginosa. Overall design: Transcriptomic analysis of 2 nearly bacterial strains of Pseudomonas aeruginosa.

为进一步明确铜绿假单胞菌（Pseudomonas aeruginosa）PA14相较于铜绿假单胞菌PAO1的毒力增强成因，本研究通过RNA测序技术开展转录组学分析。下一代测序（Next-generation sequencing, NGS）已彻底革新了基于系统的转录组通路分析方法。本研究的目标为比对这两株近缘铜绿假单胞菌全部5263个直系同源基因的转录组特征。整体实验设计：对两株近缘铜绿假单胞菌进行转录组学分析。