MIC determination for different antibiotics using WT, ΔabeD and ΔabeDΩabeD.

E-strips were used to determine the precise MIC for different group of antibiotics such as amikacin, cefepime, ceftriaxone, ertapenem, erythromycin, gentamicin, neomycin, norfloxacin, piperacillin, rifampicin, tobramycin and vancomycin following the CLSI guidelines. Units for MIC values are mg/L and only few representative drugs are shown here.a Fold change is the ratio of MICs for WT and ΔabeD.MIC determination for different antibiotics using WT, ΔabeD and ΔabeDΩabeD.本研究依照临床和实验室标准协会（Clinical and Laboratory Standards Institute, CLSI）指南，采用E试验条（E-strips）测定阿米卡星、头孢吡肟、头孢曲松、厄他培南、红霉素、庆大霉素、新霉素、诺氟沙星、哌拉西林、利福平、妥布霉素以及万古霉素等多类抗生素的精确最低抑菌浓度（minimum inhibitory concentration, MIC）。MIC值的单位为mg/L，本次仅展示了部分代表性药物的数据。注a：变化倍数为野生型（wild type, WT）菌株与abeD基因缺失株（ΔabeD）的MIC比值。本研究采用野生型菌株、abeD基因缺失株以及abeD基因互补株（ΔabeDΩabeD）对不同抗生素开展MIC测定。