Lymphatic vessel endothelial cell lines sequencing

We found interferon gama could upregulated adhesion molecules expression in lymphatic vessel endothelial cells and promotes cells adhesive to lymphatic vessel endothalial cells. We discovered the mechanisms about adherence of myeloid depressive cells with lymphatic vessel endothalial cells, which could allow admittance of myeloid depressive cells to lymphatic vessels and reveal that the pathway may represent a potential signaling axis to mediate tumor progression in melanoma.

本研究发现，干扰素γ（Interferon Gamma）可上调淋巴管内皮细胞（Lymphatic Vessel Endothelial Cells）中的黏附分子表达，并促进细胞黏附于该类内皮细胞。我们阐明了髓系抑制性细胞（Myeloid Depressive Cells）与淋巴管内皮细胞的黏附机制，该机制可介导髓系抑制性细胞侵入淋巴管，同时揭示这一信号通路或可作为介导黑色素瘤（Melanoma）肿瘤进展的潜在信号轴。