Quantification of fragile telomeres in wild-type and Nth1−/− mouse bone marrow cells and primary MEFs treated with a low dose of aphidicolin.

Values indicate percentage of fragile telomeres. Bone marrow cells (6 mice) and MEFs (4 lines) are treated with aphidicolin for 16 hours. At least 50 metaphases are counted.*denotes P-values that yield significant difference compared with wild type (untreated).数值代表脆性端粒（fragile telomeres）的占比。以阿非迪霉素（aphidicolin）处理来自6只小鼠的骨髓细胞与4株小鼠胚胎成纤维细胞（MEFs），处理时长为16小时。至少计数50个分裂中期相。*代表与野生型（未处理组）相比存在显著性差异的P值。